A WAY TO INCREASE EFFECTIVENESS OF PARACETAMOL DRUG THROUGH TRANSDERMAL PATCH

Abstract

Millions of people around the world suffers from the fever, effective treatment is essentialby formulatingTransdermal patch. Paracetamol IP traditionally considered as a NSAID, is an effective analgesic and antipyretic fully soldwithout prescription. The conventional formulations containing high dose as well as required to take the medication frequently so increase the risk factor associated with drug. The present study is an attempt to developsuitable matrix type patch of Paracetamol usingblends of XanthanGumand HPMC K4M with polyethylene glycol (PEG-400) as a plasticizer.To get bettereffectpermeation enhancers such as Linseed oil and oleic acid was also incorporated and their optimum concentration was determined. Prepared formulations were evaluated for compatibility, drug content,moisture lossand absorption,thickness, weight variation, adhesion, folding enduranceetc.In vitro permeation study was performed by using Franz diffusion cell. Formulations were found to be uniform in physicochemical parameter with a fewer variations and there was no significant interaction between drug and polymer used. Formulation of HPMC K4M alongwith Linseed oil showed faster release of drug from developed formulations. Based on the observation, No burst effect but HPMC K4M are better for faster releasewith linseed oil and xanthangum for prolonged releasefor the development of patch.Stability studies indicated the formulations were remained stable both physically and chemically. Alldeveloped formulations showed desired properties of an ideal TDDS and followed zero order rate profile.Thus, the study achieved targetsby reduction in frequency of administration and systemic toxicity.