INVESTIGATING THE CORRELATION BETWEEN GESTATIONAL DIABETES MELLITUS AND URIC ACID

Abstract

Background: In the second or third trimester of pregnancy, there is an increased chance of developing gestational diabetes mellitus in some pregnant women who had high uric acid levels in the first trimester. There is a dearth of literature to evaluate this relationship among Indian girls.
Aim: The purpose of this study was to evaluate the early pregnancy blood uric acid level in order to predict the development of gestational diabetes mellitus.
Methods: 168 females who are less than 13 weeks pregnant in the first trimester of their pregnancy are evaluated in this study. The assessment of uric acid was conducted using the calorimetric technique, with a detection limit of 10 mg/dl. The DIPSI-recommended technique was applied during 24-48 gestation weeks in order to evaluate gestational diabetes mellitus. The main finding of the study was the relationship between blood uric acid levels and the development of gestational diabetes mellitus. The secondary finding was the relationship between the development of diabetes mellitus and high-risk variables, age, and body mass index (BMI).
Results: 168 pregnant women were evaluated in the research. With 51.19% (n=86) of the patients being female, 85.71% (n=144) having a BMI of less than 25 kg/m2, and 64.88% (n=109) of the subjects being primigravida, the majority of the research participants were between the ages of 21 and 25. Twenty participants, or 11.90%, exhibited high risk factors. In 16.07% of cases (n=27), serum uric acid levels were more than 3.5 mg/dl. Of the 13 study females, 7.73% had gestational diabetes mellitus, and 12 had elevated blood uric acid. With p=0.0003, increased age was the major risk factor for the development of gestational diabetes mellitus.
Conclusions: The current study suggests that when blood uric acid levels are greater than 3.5 mg/dl, pregnant women who have known high-risk factors for gestational diabetes mellitus are at risk of acquiring the disease. Additionally, elevated blood uric acid levels in the first trimester of pregnancy can serve as a trustworthy indicator for predicting the onset of gestational diabetes mellitus.