ANTIOXIDANT, ANTI-CANCER AND ANTICOAGULANT PROPERTIES OF ETHANOLIC EXTRACT OF TAMARINDUS INDICA SEED COAT

Abstract

The existing piece of work validates the antioxidant, anticancer and anticoagulant properties of Ethanolic Extract of Tamarindus Indica Seed Coat 
(EETISC). The feasible secondary metabolite in the EETISC extract was analysed on the RP-HPLC column chromatography with PDA detector. In 
addition, the extract showed DPPH and superoxide radicals scavenging activities supporting its antioxidant activity. Curiously, EETISC extract showed 
anti-cancer activity as it exhibited potent pro-apoptotic activity in the EAT tumour model and the antiangiogenic properties in chorioallantoic membrane 
assay. Interestingly, EETISC showed anticoagulation property by inhibiting intrinsic pathway of blood coagulation cascade, suggesting its therapeutic 
potential in cardio and cerebrovascular complications. Moreover, EETISC extract did not cause edema and haemorrhage in the experimental mice study 
and did not hydrolyze RBC’s suggesting its nontoxic property. In conclusion, EETISC is exhibited manifold therapeutic applications thus it may be a 
promising therapeutic agent for worries such as oxidative stress, cancer cells and thrombosis.