DEVELOPMENT AND EVALUATION OF FLOATING TABLET CONTAINING NEVIRAPINE USING A 32 FULL FACTORIAL DESIGN OPTIMIZATION METHOD
Keywords:
Nevirapine, gastric retention time,, dependent and independent variables,Abstract
Floating oral drug delivery system is retained in the stomach and are useful for drugs that are poorly soluble or unstable in intestinal fluids. Nevirapine
are the suitable drug candidates for the formulation of floating sustained drug delivery system. Nevirapine is a non-peptic, protease inhibitor
antiretroviral drug used in the treatment of the human immune deficiency virus. Floating tablet of Nevirapine is prepared with a view to attain early
onset of action and giving prolonged release of Nevirapine by enhancing gastric retention time. A 3 full factorial design by Design Expert software
was used for the development of floating sustained release tablet in which the composition of release retardant polymer and effervescent agent were
incorporated as two independent variables or factors. Compatibility study was carried out by FTIR study. The regression coefficients and the analysis
of variance information is well exposed. It was observed that as the concentration of the HPMC K4M increased the percentage of swelling also increased.
The percentage of swelling was determined at the end of 8 h for all the developed formulations. The buoyancy lag time was measured by using stop
watch and total floating time was observed visually. Floating lag time was observed less than 78 sec for all batches. Total floating time was observed
more than 12 h. Hence, this new type of floating sustained release tablet which can transfer to industry scale production with high output rates by
considering the need of nevirapine.
