SYNTHESIS, ANTIFUNGAL AND ANTI BACTERIAL ACTIVITY OF N-(4-CHLORO-2-TRIFLUOROACTYL PHENYL) - AMINOTHIAZOLE DERIVATIVES

Abstract

In this study,1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone was synthesized by reacting p-chloroaniline with ethyl trifluroacetate in presence of 
n-butyl lithium, further reacting with  ammonium thiocyanate with hydrochloric acid leads to 1-(4-chloro-2-(2,2,2-trifluoroacetyl)phenyl)urea. Then 
reacted with ArCOCH2Br and sodium acetate gave 1-{5-chloro-2[(4-substituted-1, 3-thiazol-2-yl) amino] phenyl}-2,2,2-trifluroethanone derivatives. 
The chemical structure of newly synthesized compounds has been confirmed on the basis of elemental analysis, IR, 1H NMR and Mass spectral data. 
The newly synthesized compounds were screened for their antibacterial activity invitro against Gram-positive bacteria namely Escherichia coli, 
Staphylococcus aureus, and Gram-negative bacteria namely Pseudomonas aeruginosa, Bacillus subtilis and the fungus namely Candida albicans by disc 
diffusion method. Among the synthesized compounds 5b, 5f, 5g, 5h, 5j were found to have a very good antibacterial and antifungal activity.