ULTRAVIOLET-SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN PROPANEDIOL AND METFORMIN HYDROCHLORIDE

Abstract

Two simple, precise and economical UV spectrophotometric methods have been developed for the simultaneous estimation of Dapagliflozin and 
Metformin in bulk drug and marketed formulation. In simultaneous equation method, 223 nm (λmax of DAPA) and 233 nm (λmax of MET) analytical 
wavelengths were selected and analysis were carried out. In area under curve method, 220-229 nm (λmax of DAPA) and 229-236 nm (λmax of MET) 
wavelengths were selected and analysis were carried out. The method was validated using various parameters according to ICH guidelines. The low 
relative standard deviation values indicate good precision and high recovery values indicate accuracy of the proposed method. Assay results were in 
good agreement with label claim.