SALIVARY UREA AND CREATININE'S EFFECTIVENESS AND CORRELATION WITH BLOOD UREA AND CREATININE IN PATIENTS WITH SEVERE RENAL DISEASE
DOI:
https://doi.org/10.56802/kvb9kp76Keywords:
urea, creatinine, serum, saliva, chronic kidney diseaseAbstract
Background: Because of aging and the growing burden of non-communicable illnesses, there is an increasing prevalence of chronic kidney disease (CKD) worldwide. CKD patients accumulate a number of waste products as a result of impairment, which leads to a number of metabolic problems. They must thus have hemodialysis repeatedly in order to survive. As a result, blood urea and creatinine levels must be regularly checked. Saliva is becoming a popular medium for assessing these characteristics, nevertheless, because it is non-invasive.
Aim: The purpose of this study was to evaluate the effectiveness of serum urea and creatinine in patients with severe renal disease as well as the relationship between these parameters and salivary urea and creatinine in patients with chronic kidney disease.
Methods: The 200 participants in this study were split into two groups of 100 each, with CKD individuals in Group I and age- and gender-matched control subjects in Group II. Samples of blood and saliva were taken from each individual, and the levels of creatinine and urea were measured and compared. The collected data were subjected to statistical analysis.
Results: The study's findings demonstrated that the levels of creatinine and urea in the blood and saliva samples of the two groups differed significantly. Salivary urea and creatinine levels were also shown to be strongly positively correlated with serum urea and creatinine levels, respectively. The maximum specificity and sensitivity were seen for salivary creatinine at a cut-off value of 0.8 mg/dl and blood urea at 40 mg/dl.
Conclusion: salivary urea and creatinine levels can be utilized in place of blood urea and creatinine for determining eGFR and staging chronic renal disease. Additionally, as saliva collection is non-invasive, it may be utilized in place of blood sample collection, which is invasive, for the diagnosis and follow-up of CKD patients.
