"Design, Optimization, and In-Vitro Evaluation of Chitosan-Coated PLGA Nanoparticles for Targeted Delivery of Doxorubicin to Breast Cancer Cells"

Authors

  • Johny Lakra Author
  • Suhas Narayan Sakarkar Author
  • Reeta Shakya Author
  • Anil Kumar Author
  • Sanju Singh Author
  • Preeti Singh Author
  • Yash Srivastav Author
  • Nirbhay Kumar Yadav Author
  • Rohini Armo Author

DOI:

https://doi.org/10.56802/a8xjfj80

Keywords:

Breast cancer;

Abstract

Background
Breast cancer remains one of the leading causes of cancer-related mortality among women
globally. Despite doxorubicin (DOX) being a widely used chemotherapeutic agent, its efficacy is limited by systemic toxicity and non-specific distribution. Nanoparticle-based drug delivery
systems offer a promising strategy to enhance therapeutic index and reduce adverse effects.
Objective
To develop and evaluate chitosan-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles for
targeted and controlled delivery of DOX to breast cancer cells.

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Published

18-08-2025

Issue

Vol. 16 No. 8 (2025): Volume 16 Issue 8 2025

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

"Design, Optimization, and In-Vitro Evaluation of Chitosan-Coated PLGA Nanoparticles for Targeted Delivery of Doxorubicin to Breast Cancer Cells". (2025). International Research Journal of Pharmacy, 16(8), 25-39. https://doi.org/10.56802/a8xjfj80