EFFECT OF BMI ON LEVELS OF SERUM MAGNESIUM IN SUBJECTS ON PRITCHARD REGIMEN

Abstract

Background: Maternal mortality from severe eclampsia and preeclampsia has reduced significantly in developed nations
from revolutionary management by magnesium sulfate, however, it is high in developing nations such as India. Various
factors including BMI can significantly affect serum magnesium levels in subjects getting therapeutic and prophylactic
management using the Pritchard regimen.
Aim: The present study aimed to assess the effect of BMI (Body mass index) on serum magnesium levels in Pritchard
regimen subjects and magnesium sulfate therapy subjects for prophylaxis of seizures.
Methods: The present study assessed 320 subjects with severe preeclampsia and eclampsia who were under the Pritchard
regimen within the defined study period. In all the included subjects, serum magnesium levels were assessed after the
loading dose, the third dose, and 24 hours after the last dose. Subjects were divided into various groups based on the WHO
BMI category. The data gathered were statistically analyzed