THIAZOLIDIN-4-ONE DERIVATIVES ON HUMAN LUNG FIBROBLAST SHOWS OXYGEN FREE RADICAL SCAVENGING ACTIVITY

Abstract

The antioxidants are proving crucial tools in the exploration of oxidant stress-related diabetic pathologies and despite the noticeable prospective merit
of the safety and efficacy of antioxidant supplementation in any future treatment remains to be conventional. The development of innovative methods
for the synthesis of five-member heterocyclic compounds is an ever-expanding area in bioorganic and medicinal chemistry. Specifically, those
containing the thiazolidinedione ring have been expansively used as key building blocks for synthesizing various drugs. In present study we endeavor
to display a more chemically versatile and diverse thiazolidin-4-one derivatives as a suitable pharmacophore for antioxidant activity. Antioxidant activity
was evaluated by using both enzymatic and non-enzymatic activities such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase
(GPX) on cell lines and free radical scavenging activity by DPPH (1, 1-diphenyl-2-picryl-hydrazil) assay method and ferric reducing antioxidant power
(FRAP) assays. Finally, all tested compounds exhibited a talented antioxidant activity. In addition, all the synthesized derivatives showed non-toxic
effects against a diseased human lung fibroblast (COPD), HCC7231 (TACC CCL-96). In prospect study, the movement of the compounds may be
manipulated by optimizing a lead molecule by introducing un-saturation or heterocyclic ring at C5 of thiazolidinediones. The outcomes of such studies
may be positive for the clinical applications in humans and may open up a new therapeutic avenue.