NEURODEGENERATIVE DISEASES: AN OVERVIEW

Abstract

Neurodegenerative diseases are traditionally defined as disorders with selective loss of neurons and distinct involvement of functional systems defining
clinical presentation. The neurodegenerative diseases affect a significant number of individuals in all age groups. The common features of multiple
neurodegenerative diseases, such as abnormalities in protein degradation pathways, mitochondrial dysfunction, compromised axonal transport processes
and ultimately induction of cell death pathways. These aberrant processes originate in and in many cases remain restricted to, specific regions and cell
types within the CNS. This review can provide impulsion for investigators to take on molecular mechanism with the ultimate hope of finding a cure for
the devastating neurological diseases.