AIRWAY COLLAPSIBILITY FOLLOWING A SINGLE INDUCTION DOSE OF KETAMINE WITH PROPOFOL AND PROPOFOL SEDATION IN CHILDREN UNDERGOING MRI

Abstract

Background: Adequate sedation is required for young participants receiving an MRI console. Propofol is a commonly used
sedative; nevertheless, at large dosages, it causes upper respiratory collapse, which can be compensated for by ketamine.
Aim: To compare airway collapsibility following a single induction dose of ketamine with propofol-to-propofol sedation in
children participants undergoing MRI.
Methods: The study evaluated 116 children patients who had MRI and were randomly separated into two groups: Group I
received a propofol bolus followed by an infusion, and Group II received a bolus propofol and ketamine followed by a
propofol infusion.
Results: Upper airway diameters [APD (anteroposterior diameter) and TD (transverse diameter)] and cross-sectional area
(CSA) were measured in both groups using MRI during expiration and inspiration. The study found that upper airway collapse
measured by delta CSA was significantly higher in some groups than others, with mean values of 16.7±19.7mm2 at the soft
palate, 15.2±11.01mm2 at the base of the tongue, and 23.7±26.03mm2 at the epiglottis (p=0.03). A statistically significant
difference was seen in transverse diameter at all levels, as well as anteroposterior diameter at the base of the tongue and soft
palate.
Conclusion: The current study concluded that adding a single dosage of ketamine to propofol can considerably prevent upper
airway collapse with the evidence from MRI-based measurements of upper airway dimensions compared to propofol alone.