THREE – COMPONENT REACTION OF 3 – NITRO BENZALDEHYDE, ISOPROPYL ACETOACETATE AND 1- BENZHYDRYLAZETIDIN – 3- YL - 2 AMINO – 2- IMMINOACETATE IN PRESENCE OF POTASSIUM CARBONATE: AN EFFICIENT ONE-POT SYNTHESIS OF 1, 4-DIHYDROPYRIDINE DERIVATIVE

Abstract

A new and efficient one-pot synthesis of 1, 4 – dihydropyridine derivative by three component reaction 3 - Nitro benzaldehyde, isopropyl acetoacetate and 1- benzhydrylazetidin -3 - yl - 2 amino - 2 - imminoacetate in presence of dimethylformamide is described. The reaction was performed in dimethylformamide at 90⁰C and mild basic condition.