PRE-CLINICAL INVESTIGATION OF ANTI-TUSSIVE ACTIVITY OF HIBISCUS ROSA-SINENSIS ON GUINEA PIG

Abstract

Ayurveda suggests that decoction of leaves of Hibiscus rosa-sinensis could be beneficial to reduce cough. Codeine and other synthetic antitussive agents shows number of side-effects and thus to find better and safer alternate Hibiscus rosa-sinensis was evaluated for its antitussive activity.Dried powder of flower part of Hibiscus rosa-sinensis was extracted with methanol and the practical yield of methanolicextract was found to be 1% W/W.Anti-tussive effect of methanolic extract of Hibiscus rosa-sinensis was studied in Histamine chamber using citric acid (7.5%W/V) induced cough model, in which the methanolic extract of Hibiscus rosa-sinensis significantly decreased the number of coughing. From this we concluded that methanolic extract of Hibiscus rosa-sinensis possess antitussive activity.