AN OVERVIEW OF GASTRORETENTIVE DRUG DELIVERY SYSTEM RESEARCH

Abstract

The reason of writing this research article on gastro retentive drug delivery systems was to gather the recent literature with special focus on various gastro retentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to identify with various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastro retentive approaches designed and developed until now, i.e. microspheres, microcapsules, floating gel beads, floating matrix tablets and in-situ gel, with advantages and limitations of gastro retentive drug delivery systems in detail.