DEVELOPMENT AND EVALUATION OF THEOPHYLLINE MICROBALLOONS DRUG DELIVERY SYSTEM

Abstract

The objective of the present investigation was to prepare theophylline microballoons loaded with sodium alginate, eudragit S 100 and sodium bi-carbonate as gas generating agent. The microballoons prepared by ionotropic gelation method were analysed for morphology, mean particle size, drug polymer interaction, entrapment efficiency and in-vitro drug release.