A NOVEL EXPLORING APPROACH OF CANCER CHEMOTHERAPY BY MULTIPLE EMULSION SYSTEM

Abstract

Cancer is a disease characterized by uncontrolled multiplication and spread of abnormal forms of the body's own cells, leading cause of death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) in 2008. Most common cancers are Lung, Liver, Colon, Rectum, Breast Ovarian & Prostate cause the most deaths each year. Lung cancer is the most frequent lethal cancer, 1.4 million cases per year by use of long-term exposure to tobacco smoke. Chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen. Attempts to treat tumors with the single agents are often disappointing. A single drug usually kills the most sensitive population of cells in a tumor, leaving a resistant fraction unharmes and still dividing. Therefore, each time the same agent is readministered, the tumor becomes more resistant and the treatment less efficacious. The parenteral Sustained release dosage forms are most effective and common form of delivery for active drug substance & designed to achieve a prolonged therapeutic effect by continuously releasing medication over extended period of time after administration of single dose. For this reason whatever drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in term of compliance but also for potential to improve the quality of the therapy. Such reduction in the frequency of drug is achieved, by the use of specific formulation technologies that guarantee that the release of the active drug substance happens in a slow and predictable manner. Multiple emulsions of w/o/w and o/w/o type are becoming popular since an additional reservoir is presented to the drug for partitioning which can effectively retard it release rate.