SYNTHESIS AND EVALUATION OF NOVEL THIAZOLIDINEDIONE DERIVATIVES FOR ANTIDIABETIC ACTIVITY

Abstract

The aim of study was to synthesize a new series of thiazolidinedione’s. Thiazolidinedione’s or glitziness forms a significant class of drugs which exhibit biological activities ranging from antidiabetic, anti-inflammatory, antibacterial, antifungal, antiviral and anticancer. In the present study reported a systematic synthesis of thiazolidinedione analogues. A new series of 2, 4-thiazolidinedione based derivatives have been synthesized by the condensation of various substituted phenoxy benzene amines and 4’-chlorosulphonyl 5-benzylidene-2, 4-thiazolidinedione. The structure of these compounds were established by IR and ¹H NMR. These new compounds (F1 – F7) were evaluated for their antidiabetic activity on albino rats. Most of the compounds showed significant antidiabetic activity when compared with the standard drug metformin.