NONSURGICAL ASSESSMENT OF INTRALESIONAL THERAPIES IN CUTANEOUS WARTS – RETROSPECTIVE CLINICAL STUDY

Abstract

Background: Treatment options for different kinds of cutaneous warts may vary depending on the place. Immunotherapy has been quite popular lately, particularly for cases with resistant warts.
Aim: In order to treat numerous cutaneous warts, the current study set out to compare the effectiveness of four immunotherapeutic agents: vitamin D3, candida extract, PPD (purified protein derivative), and MMR (measles, mumps, and rubella).
Methods: The study included 200 people with numerous (>5) cutaneous warts. The subjects were randomly assigned to four groups, Group I, II, III, and IV, and received treatment with MMR, PPD, Candida extract, and Vitamin D, in that order. The intralesional injections were administered at three-week intervals for a maximum of three doses, with the wart chosen as the target based on the group. The response was seen in distant and target warts three months after the last injection.
Results: When it came to the removal of the target warts, intralesional vitamin D3 showed the most efficacy whereas MMR showed the lowest efficacy. Intralesional candida extract demonstrated the best efficacy in clearing remote warts, whereas vitamin D3 demonstrated the lowest efficacy. Intralesional candida extract was the most successful therapy for both distant and localised warts. The side effects were mild and only temporary.
Conclusion: The current study comes to the conclusion that the most effective, economical, and secure way to treat cutaneous warts is using intralesional immunotherapy.