REVIEW ON SOLUBILITY: A MANDATORY TOOL FOR PHARMACEUTICALS

Abstract

Solubility of drug substance is a major issue in Pharmaceutical area. If drug product is to be administered orally in solid form, then it is mandatory
that the drug product must solubilized within the gastro-intestinal fluid prior to absorption, and if drug product fails to do so then the patient will not
achieve the required therapeutic effect. Now-a-days solubility is a major issue for Pharmaceutical dosage forms. Almost 30% to 40% of the upcoming
drug substances have low water solubility. Solubility of pharmaceutical products defines the bioavailability and absorption of a drug. By improving
solubility, the dissolution behavior of any drug can also be improved. Therapeutic effectiveness of drug product depends on its bioavailability, and
ultimately on solubility of the drug product.