DESIGN, SYNTHESIS AND ANTICANCER ACTIVITY OF STRUCTURALLY MODIFIED 1, 3, 4-OXADIAZOLE INCORPORATED 2H-CHROMENE DERIVATIVES AS ANTICANCER AGENTS
Keywords:
Amlexanox, Zibotentan, 2H-chromene, 1, 3, 4-oxadiazole and anticancer activity.Abstract
This paper reports the synthesis of a series of 1, 3, 4-oxadiazole incorporated chromene derivatives (9a-j) were synthesized and their chemical structures
were firmed by 1HNMR, 13CNMR and mass spectral examination. Further, all these target compounds were investigated for their anticancer activity
towards four human cancer cell lines including MCF-7: human breast, A549: human lung, DU-145: human prostrate and MDA MB-231: human breast,
by using MTT assay method and obtained results were expressed in IC50 µM. Here etoposide used as standard drug and most of the compounds were
showed good to moderate activity than positive control. Among all synthesized compounds, five compounds (9b, 9f, 9g, 9i and 9j) were displayed more
potent activity than etoposide.
