PREPARATION AND EVALUATION OF FLUVASTATIN EXTENDED RELEASE TABLETS USING NEEM GUM

Abstract

Extended release dosage forms prolong and control the release of the drug that is dissolved or dispersed in a matrix system is one of the widely used 
approaches in pharmaceutical dosage forms. Majority of the polymers either from natural or synthetic origin is used as matrix forming agent in 
pharmaceutical dosage forms. There are many benefits of using natural gums in drug delivery. Recent past has witnessed the application of natural 
gums and mucilage’s as pharmaceutical aids in drug delivery. The present study was planned with an objective to develop fluvastatin extended release 
tablets by using neem gum as matrix forming agent. The prepared tablets were evaluated for their physicochemical properties, drug content and in vitro 
drug release. The results of the study indicated the usefulness of neem gum as pharmaceutical excipient for the preparation of extended release dosage 
forms.