ANTIUROLITHIATIC ACTIVITY OF SESAMUM INDICUM LEAVES AGAINST ETHYLENE GLYCOL INDUCED UROLITHIASIS IN RATS
Keywords:
Calcium oxalate,, ethylene glycol,, urolithiasis, uric acid, creatinine.Abstract
The present study was undertaken to investigate the effects of Sesamum indicum (leaves) on experimentally induced kidney stones. Oxalate urolithiasis
in male rats was induced experimentally by administration of 0.75% v/v ethylene glycol in drinking water for 28 days. The aqueous and alcoholic
extracts of Sesamum indicum were administered to urolithiasis induced test group rats at three doses i.e. 100, 200 and 400 mg/kg respectively for 28
days. After 28 days, highly significant deposition of calcium oxalate in the kidneys was noticed along with increase in the urine volume, urinary oxalate,
calcium levels and magnesium levels in urolithiasis induced group rats as compared to normal group rats. The serum analysis showed significant
increase in the serum uric acid, serum creatinine, and blood oxalate in urolithiasis control group rats. Daily oral treatment with extracts not significantly
reduced the quantity of calcium oxalate deposited in the kidneys but also reverted all the biochemical changes induced by ethylene glycol urolithiasis
thus supporting its traditional claim.
