COMPARATIVE ASSESSMENT OF FOUR IMMUNOTHERAPEUTIC AGENTS IN THE TREATMENT OF MULTIPLE CUTANEOUS WARTS

Abstract

Background: Depending on the kind of cutaneous wart, several treatment approaches may be needed. Some patients may
benefit from a combination of several therapy techniques. Immunotherapy has been quite popular recently, particularly for
cases with resistant warts.
Aim: In order to cure numerous cutaneous warts, the current study compared the effectiveness of four immunotherapeutic
agents: vitamin D3, candida extract, PPD (purified protein derivative), and MMR (measles, mumps, and rubella).
Methods: 200 individuals with more than five cutaneous warts were randomly assigned to four groups, and the subjects in
Group I, II, III, and IV received treatments with MMR, PPD, Candida extract, and vitamin D, respectively.
The objective was a wart, and intralesional injections were administered to the group at 3-week intervals for a maximum of
three treatments. Three months following the previous injection, both remote and target warts showed signs of response.
Result: MMR had the lowest efficacy in terms of clearing the target warts, whereas intralesional vitamin D3 had the most
efficacy. Vitamin D3 showed the lowest efficacy in clearing the remote warts, whereas intralesional candida extract showed
the maximum efficacy. Intralesional candida extract proved to be the most successful therapy for both local and distant warts.
The side effects were mild and short-lived.
Conclusion: The current study comes to the conclusion that the most effective, reasonably priced, and secure method of
treating cutaneous warts is intralesional immunotherapy.