DEVELOPMENT AND CHARACTERIZATION OF BAMBOO BASED WOUND DRESSING COATED WITH NATURAL EXTRACTS OF CURCUMIN, ALOE VERA AND CHITOSAN ENHANCED WITH RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR AND IN VIVO EVALUATION FOR WISTAR ALBINO WOUNDED RATS

Abstract

Development of natural fibres based wound dressing material coated with different compositions of aloe vera, curcumin and Chitosan enhanced with
rhEGF for wound healing applications was explicate in this research work. The coated fabrics were subjected to mechanical properties, anti-bacterial
test and Scanning Electron Microscopy. Justifying more on these findings, the coated fabric samples were tested for its wound healing efficacy was
studied by in vivo method of wound healing using Wister Albino rats. The dorsal surface of the rat’s skin was removed and created a full – thickness
wound. Then the developed fabric samples loaded with rhEGF were applied over the wound surface and the wound closure was studied in equal
interval of days. The formation of zone of inhibition in antibacterial test and wound closure rate in In Vivo evaluation reveals that a specified
composition of natural extracts of Aloe vera, curcumin and solution of Chitosan enhanced with rhEGF reveals that coated fabric samples exhibits
good antibacterial property and higher rate of wound healing nature. Hence therefore these coated fabrics can be suitable for faster wound healing
process.