RELATIONSHIP BETWEEN ACNE VULGARIS AND HIRSUTISM TO INSULIN RESISTANCE AND TO ASSESS THE SEVERITY OF TWO CONDITIONS WITH INCREASED INSULIN RESISTANCE

Abstract

Background: Acne and hirsutism are common disorders that are simple to cure. They do, however, have a noticeable 
effect on how one perceives oneself. There is a lot of research on the pathophysiology of acne and hirsutism, and insulin 
resistance is one of them. They are not fully understood, though.  
Aim: The purpose of this study was to determine how insulin resistance is related to acne vulgaris and hirsutism, as well 
as to evaluate how severe these two disorders are when it comes to insulin resistance.  
Methods: A thorough clinical history was taken of each included individual, and then measurements such as height, 
weight, and BMI were noted, along with any indications or symptoms of underlying insulin resistance. The global acne 
grading system, or GAGS, was used to grade acne, while the modified Ferriman Gallwey score (mFG) was used to 
determine the severity of hirsutism. Results were formulated by analysing the data. 
Results: Three groups of 174 patients were created, and the group with only acne (154 subjects) showed a strong 
association (p<0.0001) between acne severity and insulin resistance with recurrence. Twelve participants in the hirsutism
only group had a high association between the HOMA-IR and the mFG score and recurrence, indicating greater hirsutism 
severity and increased insulin resistance (p<0.0001 and p<0.007, respectively). Not severity, but BMI and insulin 
resistance were positively correlated in the combined hirsutism and acne group. 
Conclusion: The current study comes to the conclusion that insulin resistance plays a significant role in the 
pathophysiology of hirsutism and severe, resistant acne. Since insulin resistance can have a substantial effect on the 
psychological well-being of those afflicted, treating these disorders may need a different strategy.