ANTIOXIDANT AND ANTIDIABETIC ACTIVITY ON ROOTS OF SMILAX ZEYLANICA

Abstract

Objective:  To evaluate the antidiabetic and antioxidant activity on Smilax zeylanica. Materials and methods:  The different extracts of Smilax zeylanica 
was studied for antidiabetic activity in streptozotocin induced diabetic rats by oral administration of extract 400mg/kg body weight for 21 days. The 
effect was compared with oral dose of 0.5mg/kg Glibenclamide and the extracts were also studies for antioxidant activity by DPPH radical scavenging 
activity. Results: The methanolic extract of Smilax zeylanica roots shows the better results as compared to other extracts and in phenol and Flavonoid 
content estimation methanolic extract showed the better results. The Phytochemical investigation showed the presence of phenol, flavonoid, glycosides, 
alkaloids Saponins. Conclusion: The existence of phenolic and flavonoid compounds in the extract may be accountable for the antidiabetic and 
antioxidant activity. Thus this activity can be contributed to the phytochemicals present in it. The methanolic extract of Smilax zeylanica can be 
concluded to possess highest amounts of phenolic, flavonoid and DPPH free radical scavenging activities from the present studies.