THE EFFECT OF VIRGIN COCONUT OIL (VCO) AS AN ANTIDIABETIC AND ON LIPID PROFILE IN ALLOXAN –INDUCED WHITE MALE MICE (MUS MUSCULUS)

Abstract

Virgin Coconut Oil (VCO) is a supplement with contain short and medium chain fatty acids, mostly high Lauric acids. which quickly absorbed by the 
body and converted to energy. The purpose of this study was to determine the effect of giving VCO toward blood glucose metabolism and to observe 
the profile lipids in white male mice (Mus musculus) after inducing alloxan. This study used an experimental method using 5 groups and 40 white male 
mice. Those were negative control group, positive control group, diabetes group with glibenclamide, diabetes group with 2% VCO dose and diabetes 
group with 4% VCO dose. The data was analyzed using Kruskal-Wallis. The results obtained showed that VCO has an effect on glucose metabolism, 
lipid in diabetic mice which injected 4% dose of VCO was able to reduce the blood glucose level by 151.75 mg/dl or reduce it by 55%. VCO dose of 
2% can reduce total cholesterol, triglycerides, LDL with a total cholesterol value of 145.83 mg/dl, triglyceride 143.50 mg/dl, LDL 55.88 mg/dl and 
increase HDL with value of 61.16 mg/dl.