DEVELOPMENT AND EVALUATION OF NANOCARRIERS OF AN ANTICANCER DRUG FOR THE TREATMENT OF BREAST CANCER
Keywords:
Docetaxel,, Nanoparticles, Anti solvent precipitation, Pluronic F68.Abstract
The current goal of the research work was to develop and evaluate Docetaxel nanoparticles as potential carrier system to facilitate targeted delivery to
tumour cells. Central composite design was used to optimize Docetaxel loaded Pluronic F68 nanoparticles. Drug loaded Pluronic F68 nanoparticles
were prepared by anti solvent precipitation method and was characterized for FTIR, DSC, Entrapment efficiency, Drug Content, % Yield, SEM and in
vitro release studies. Docetaxel with Pluronic F68 showed no interaction based on the results from FTIR and DSC. Polymer concentration affected the
entrapment efficiency, drug content and percentage yield. The more the polymer concentration the more was the yield, the more was the entrapment
efficiency. The in-vitro release study was performed and at 12th hour the release ranged between 81.28-91.71 %. The average particle size was found to
be 62.51 nm.
