STUDY ON EFFECTS OF CHROMIUM ON ANTIOXIDANT ENZYMES IN MICE

Abstract

Chromium, naturally occurring, largest environmental toxicant that affects human health and most common pollutant; over the last few decades, it has 
been a concern that the fresh water consisting of massive metals can be agitated because of their campaigns primarily through the fraudulent programs 
of humans, industrial and domestic programs, chromium, heavy metal, primarily in oxidation states of hexavalent. Chromium obstructs the metabolic 
pathways and despite of all the above Chromium is an essential nutrient. Chromium adverse effects at low level is not well established. Hence, the study 
intended to examine the alterations of chronic exposure to chromium at low dose on antioxidant defense enzymes in mice. Exposure to chromium 
depleted significantly in catalyses, superoxide dismutase, and GST activity (p < 0.0001) in brain, liver and kidney when compared with their respective 
control group. The catalyses are considered one of the most important free radical scavenging enzymes, and the body's secondary protection against 
oxygen metabolites produced by the transformational massive metals increased activity levels of CAT, GST and SOD formation was observed 
experimental animals. The increase in antioxidant enzymes in Cr-treated animals indicated that one of the Cr-induced toxic effects as generated free 
radicals and in turn damages cell membrane.