STUDY OF ANTI-BACTERIAL ANTIBIOTICS RESISTANCE AMONG GRAM-POSITIVE/NEGATIVE ORGANISMS IN INTENSIVE CARE UNIT OF TERTIARY CARE TEACHING HOSPITAL

Abstract

Antibiotics are chemical substances derived from microorganism that destroys or inhibits the growth of other microorganisms and is used in the treatment of external or internal infections.The main objective is toidentify and to analyze the resistant microbes to various antibacterial antibiotics inintensive care unit of tertiary care teaching hospital. It is an observational prospective study was conducted in 259 patientsfor a period of 6 months in variousICUsin a tertiary care teaching hospital.Patients who are at high risk of infection and prescribed with antibiotics were included and Patients admitted in Pediatrics, Neonatal and Oncology ICU’s were excluded.The collected data were analysed with IBM.SPSS statistics software 23.0 Version. To describe about the data descriptive statistics frequency analysis, percentage analysis were used.Thestudy population comprised of 118 (45.55%) male patients and 141 (54.4%) female patients.E.coliwasfoundto be predominantin the study. The mostsensitive organism for various prescribedantibiotics in the study was Staphylococcus(71.43%) and most resistant was Proteus(45.83%).E. colishowed more resistant to Ampicillin (50.64%) and sensitivity to co-trimoxazole(48.05%). For StaphylococcusAmoxicillinshowed more resistance (57.14%) and teicoplanin showed more sensitivity (85.71%).In caseof higher end antibiotics Teicoplanin showed more sensitivity (85.71%) towards Staphylococcuswhereas Imipenem showed resistance (39.13%) towards Acinectobacter.Majority of Gram negative shows more drug resistance. Therefore, treatment of common bacterial infections neededto be guided by culture based antibiotic susceptibility testing’s;individualisationof therapy and proper antimicrobial guidelines should be adoptedto overcome resistance.