FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE BUCCAL TABELTS CONTAINING SOLID DISPERSION OF VALSARTAN

Abstract

The goal of present research work was to formulate and characterize mucosal adhesive buccal tablets containing solid dispersion of Valsartan. Solid dispersion was prepared with three different carriers namely, Pluronic F-68, PVP K-30 and Mannitol in ratio 1:1, 1:3, 1:5 using solvent evaporation and melting method. Solid dispersion containing Drug: Mannitol in ratio 1:1 exhibited highest drug content and solubility and was further used for tablet formulation by direct compression method using Carbopol 934, HPMC K15M and SCMC as mucosal adhesive polymers. A backing membrane of ethyl cellulose was applied to promote the unidirectional release of drug. Results obtained indicated that all the physicochemical parameters were lying in acceptable limits. Formulation F4 was found to be best as it exhibited highest drug release, swelling index and mucoadhesive strength with acceptable range of other physicochemical parameters. Hence, it was determined that valsartan mucosal adhesive buccal tablets can be formulated to enhance the solubility and bioavailability. However, the properties of tablet depend upon the polymer and its concentration.