COMBINATION KARAS (Aquilaria malaccensis LAMK.) INFUSION AND ANTIBIOTICS AGAINST PATHOGENIC BACTERIA FROM DIABETIC FOOT ULCER (DFU)

Abstract

FICI used to describe the result of two compound antibacterial in resist bacterial growth so that FICI value characteristic can be known, there is 
synergistic, additive, indifferent, or antagonist. According to the background above this research purpose is to analyze FICI value from combination of 
antibiotic with karas infusion against bacteria isolate from DFU patient level III and IV Wagner. Subject taken from bacterial swab identification DFU 
level III and IV Wagner. This Research using Kirby-Bauer method with combination infusion with 25%;75%; 50%:50%; 75%:25% with Gentamicin, 
Tetracycline, and Ciprofloxacin. Based on this research combination from Karas: Gentamicin with 50%:50% showed inhibition zone (6.23+0.09 mm); 
Karas : Ciprofloxacin 50%:50% (6.37+0.21 mm), also 75%:25% for tetracycline (6.20+0.16) against Bacillus cereus. Combination and karas leaf 
infusion with the diameter zone is 50%:50% for Gentamicin (6,40+0,08 mm) and Ciprofloxacin (6.38+0.08 mm), also 75%:25% for Tetracycline 
(6.27+0.09 mm) against Microbacterium hydrocarbonoxydans. Combination Karas with the smallest diameter zone is 50%:50% with Gentamicin 
(6.42+0.08 mm), Tetracycline (6.17+0.05 mm), and Ciprofloxacin (6.33+0.12 mm) against Clostridium sphenoides. The last for Streptococcus pyogenes 
antibiotic combination Karas with the smallest diameter zone is 50%:50% for Gentamicin (9.50+0.16 mm) and Tetracycline (9.20+0.14 mm), also 
75%:25% for Ciprofloxacin (10.45+0.27 mm). All the FICI value combination were 2 means indifferent characteristic against pathogenic bacteria. We 
conclude that Aquilaria malaccensis leaves infusion combination with antibiotics can be an alternative against  infection bacteria resistant from DFU, 
however are necessary larger studies to prove their combination action.