ACETAMIDE LINKED AZETIDINONE-BENZIMIDAZOLE DERIVATIVES: SYNTHESIS AND ANTIBACTERIAL ACTIVITY

Abstract

Benzimidazoles have been considered as one of the most potent and biologically active class in medicinal chemistry. A wide variety of benzimidazole 
analogs have been synthesized so far and screened for their chemotherapeutic importance. In this study, a novel series of acetamide linked azetidinone
benzimidazole analogs have been synthesized to explore the improvement in antibacterial potential with variations in its structure. The derivatives were 
synthesized by reaction of the Schiff base of 2-phenylbenzimidazole with triethylamine, 1,4-dioxane and chloroacetyl chloride. Thin layer 
chromatography was used to check the purity of synthesized derivatives and structure of compounds was elucidated using IR, 1HNMR and mass 
spectrometry. Both Gram-negative strains (E. coli and P. aeruginosa) and Gram positive strains (S. aureus and B. subtilis) were used to check the 
antibacterial activity of synthesized derivatives with cup and plate method. Against the above-mentioned microbes, all the synthesized azetidinone
benzimidazole derivatives exhibited good activity.