ANTI DIARRHOEAL ACTIVITY OF A POLYHERBAL FORMULATION IN VARIOUS ANIMAL MODELS OF DIARRHOEA

Abstract

ABSTRACT

Diarrhea is a condition where there is an increase in defecation of a person. The subject passes watery stools. Diarrhea affects many people in developed and developing countries. Millions of people die each year due to this disease. Keeping this in mind World Health Organization encourage studies on diarrhea which include research on traditional herbal medicine. Kutaja parpati vati is a licensed polyherbal formulation which are known to be anti diarrheal in nature. But no scientific report is available for its combined anti diarrheal potential. Hence, the present study is aimed to investigate the anti diarrheal activity of the licensed polyherbal formulation Kutaja parpati vati. In this study castor oil induced diarrhea and enteropooling models were used on male wistar rats. High and low doses of the polyherbal offered significant dose dependent protection in diarrheal conditions. It significantly reduced watery diarrhea and intestinal contents conditions. Standard drug used was loperamide. Hence we can conclude that Kutaja parpati vati possesses anti diarrheal properties and the drug look promising in the treatment of diarrhea.