INVESTIGATION OF POSSIBLE HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF METHANOLIC EXTRACT OF SESBANIA GRANDIFLOR

Abstract

Sesbania grandiflora (Leguminosae: Papilionoideae), cultivate all over India, has wide range of therapeutic actions. The aim of the current study has been to investigate the possible hypoglycemic and hypolipidemic effect of methanolic extract of Sesbania grandiflora leaves. The methanolic extract of Sesbania grandiflora was tested for antihyperglycemic activity in glucose overloaded hyperglycemic rats and hypoglycemic activity in overnight fasted normal rats. The extract was also evaluated for antihyperlipidemic activity in triton-induced hyperlipidemic rats. All the methods were carried out at three dose levels, 100, 200 and 400 mg/kg respectively. The results of the study were expressed as mean ± SEM, n=6 and data was analyzed by using one way analysis of variance test (ANOVA) followed by Bonferroni's Multiple Comparison Test with 5% level of significance (P<0.05). The methanolic extract of Sesbania grandiflora exhibited significant antihyperglycemic activity (P<0.05) at 200 and 400 mg/ kg and hypoglycemic in fasted normal rats at 400 mg/ kg. It also exhibited a significant reduction (P<0.05) in serum lipid profile like total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and increase in high density lipoprotein (HDL) in triton-induced hyperlipidemic rats at 200 and 400 mg/ kg as compared to control rats statistically. All the activities were found dose dependent. These results suggested significant hypoglycemic and hypolipidemic effect of the Sesbania grandiflora, justifying the use of plant in the indigenous system of medicine