ASSESSMENT OF THE SAFETY AND EFFICACY OF PARACETAMOL IN THE MANAGEMENT OF HEMODYNAMICALLY SIGNIFICANT PATENT DUCTUS ARTERIOSUS IN PRETERM NEWBORNS

Abstract

Background: In preterm babies, hemodynamically significant patent ductus arteriosus (hsPDA) causes significant mortality
and morbidity affecting 20%very of birth weight infants where medical management is the main modality. Conventionally
used cyclooxygenase inhibitors have many serious adverse effects warranting alternative drugs such as paracetamol to be
used in NICU in preterm neonates with hsPDA.
Aim: The present study aimed to assess the safety and efficacy of paracetamol in preterm neonates having
hemodynamically significant patent ductus arteriosus (hsPDA).