SOLID LIPID NANOPARTICLES: A PROMISING DRUG DELIVERY SYSTEM

Abstract

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences. Solid lipid nanoparticles (SLNs) technology represents a promising new approach to lipophilic drug delivery. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. The biodegradable and bioacceptable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. SLNs can also be used to improve the bioavalability of drugs. In this present review this new approach is discussed in terms of their advantages, characterization, pharmacokinetic studies, in-vivo studies, in-vitro studies, and special features.