ASSESSMENT OF SYSTEMIC INFLAMMATORY INDICATORS AND THEIR CORRELATION IN ALZHEIMER'S DISEASE PATIENTS

Abstract

Background: The identification of Alzheimer's disease biomarkers can aid in tracking the illness's progression. Serum IL-6
levels are higher in people with Alzheimer's disease than in healthy individuals, according to a number of earlier research.
Serum CRP levels in Alzheimer's disease patients have been found to rise in a small number of investigations. There were
few research on albumin evaluation.
Aim: The current study sought to determine if systemic inflammatory indicators, such as albumin levels, C-reactive protein
(CRP), and interleukin-6 (IL-6), may play a part in the onset of Alzheimer's disease (AD) and whether they are related to the
severity of the illness.
Methods: In this cross-sectional study, participants with Alzheimer's disease and vascular dementia (VaD) were compared to
community-based non-demented controls (NDCs). Serum levels of albumin, CRP, and IL-6 were measured in 220 individuals
aged 50 years or older who had vascular dementia, Alzheimer's disease, and non-demented controls. A clinical dementia rating
scale was employed in order to stage the degree of dementia. In dementia subgroups, the degree of dementia was evaluated
and serum albumin, CRP, and IL-6 levels were compared.