FORMULATION DEVELOPMENT AND EVALUATION OF QUICK DISSOLVING ORAL STRIPs CONTAINING SUMATRIPTAN SUCCINATE

Abstract

The present study was aimed to formulate and evaluate quick dissolving oral strips (QDOS) of Sumatriptan succinate for the treatment of migraine headaches. Sumatriptan succinate is 5-HT1D agonist which is antimigraine. Hydroxyl propyl methyl cellulose is used as film forming agent. Quick dissolving oral strips are meant to be dissolved in saliva and remain in oral cavity until swallowed. Hence, taste masking becomes critically important. The strips were prepared by solvent casting method and characterized by UV, FTIR studies. Suitable plasticizer and its concentration were selected on the basis of flexibility, tensile strength and sticking of strip. In the present study glycerol was used as plasticizer. Strips were evaluated for drug content, the dissolution profile, disintegration time, stability studies and mechanical properties like folding endurance, percent elongation and tensile strength were found to be satisfactory. Hence, Sumatriptan succinate HPMC Quick dissolving oral strips are developed and evaluated successfully.