SYNTHESIS OF CERTAIN COUMARINYL PYRAZOLINE-5-ONE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL, ANTIOXIDANT AND ANTI-TB ACTIVITIES

Abstract

The aim of the present work was to synthesize certain coumarinyl pyrazoline-5-one derivatives and to elucidate the potential role of these compounds as antimicrobial, antioxidant and anti-tubercular agents. The coumarinyl pyrazoline-5-one derivatives were prepared by condensing the unsaturated ester of diazotized Anilines with 6-bromo substituted Coumarin-3- acid hydrazides. All the synthesized compounds showed promising anti-tubercular activity against Mycobacterium tuberculosis and some of them showed significant in vitro antioxidant activity and antimicrobial activity