EVALUATION OF THE EFFECT OF GAMBIER (Uncaria gambier) EXTRACT FOR TREATMENT OF RECURRENT APHTHOUS STOMATITIS

Siti Rusdiana Puspa Dewi; Monika Pindontha Karina Ginting; Nyimas Rafika Anggraini

Authors

Siti Rusdiana Puspa Dewi Author
Monika Pindontha Karina Ginting Author
Nyimas Rafika Anggraini Author

Keywords:

gambir extract, healing, pain, stomatitis aphthous recurrent, placebo

Abstract

needed to reduce the pain and accelerate the healing of RAS with minimal side effects. Gambier (Uncaria gambir) is used in Indonesian traditional
medicine for some oral treatments without significant side effects. This study aimed to evaluate the effect of gambier (Uncaria gambir) extract on pain
reduction and the healing of RAS. This pretest-posttest controlled group was conducted on 30 subjects. The subjects were divided into two groups;
gambier extract and placebo. They were instructed to apply gambier extract or placebo ointment three times daily for seven days. The severity of pain
was measured by using visual analog scale (VAS), the healing duration of recovered RAS was observed, and the changes in the size of the lesion were
measured using probe UNC at baseline, day 1, day 3, and day 7. Data were analyzed using SPSS ver. 22 and using two-tailed Mann Whitney and
Wilcoxon. This study showed that the pain, the healing, and the size of RAS in gambier extract group significantly reduced on the third and seventh
day compared to placebo (p<0.05). It can be concluded that gambier extract has potential effect on the treatment of RAS.