SYNTHESIS THROUGH MICROWAVE IRRADIATION, CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF 2-PHENYL-1, 3-BENZOXAZOLE DERIVATIVES

Abstract

A series of 2-phenyl-1,3-benzoxazoles were synthesized by the reaction of 2-aminophenol and acyl chlorides using microwave irradiation. Purity of compounds was determined by TLC. All the synthesized compounds were characterized by spectral analysis (FTIR, ¹H-NMR ). The compounds were evaluated for in vitro antimicrobial activity against Bacillus pumilus, Bacillus subtilis (Gram positive); Escherichia coli, Pseudomonas aeruginosa (Gram negative) and Candida albicans and Aspergillus niger by agar-well diffusion method at 2.5, 5, 10mg/ml. Compounds 2-(2-methoxyphenyl)-1,3-benzoxazole, 2-(4-bromophenyl)-1,3-benzoxazole, 2-(3-cholorophenyl)-1,3-benzoxazole, 2-(2-nitrophenyl)-1,3-benzoxazole have been found to have good antibacterial activity. Compounds 2-pheny-1,3-benzoxazole, 2-(4-bromophenyl)-1,3-benzoxazole, were potent antifungal compounds amongst the series.