COMPARISON OF INTRALESIONAL HYDROCORTISONE AND HYALURONIDASE INJECTION TO SURGICAL REPAIR IN MANGING THE ORAL SUBMUCOUS FIBROSIS: A PROSPECTIVE CLINICAL STUDY

Abstract

Background: Oral submucous fibrosis (OSMF) is one of the most frequent premalignant illnesses with a high
chance of developing into cancer. OSMF, which has a mean prevalence of 13% and a range of 0-4% depending on
the geographic area, is frequently observed in India and is linked to the chewing of betel quid.
Aim: The goal of the current study was to evaluate and compare the efficacy of two treatment modalities for OSMF
of varying degrees in order to evaluate symptoms and improvements in mouth opening. Additionally, the study
evaluated the effectiveness and improvement in mouth opening of Z-plasty surgery vs intralesional hyaluronidase
with Dexamethasone.
Methods: A total of 88 OSMF individuals with a range of grades were involved in the study. The age range of the
study participants was 20-40 years, with a mean age of 27.6±4.68 years. The subjects were split into two groups:
Group I received intralesional injections of Hyaluronidase and Dexamethasone, topical Triamcinolone Acetonide
0.1%, Placentrex, iron, and nutritional supplements; Group II received nasolabial flap repair and Z-plasty. Pallor,
mouth opening, painful ulcerations, burning sensation, and oral mucosal blanching were measured and compared at
preoperative assessment and at the one- and three-month postoperative follow-up.
Result: Patients with OSMF showed a considerable recovery after receiving both systemic and local therapy, which
included iron and nutritional supplements along with injections of dexamethasone, hyaluronidase, and topical
triamcinolone acetonide 0.1%.
Conclusion: The current study comes to the conclusion that both surgical and conservative management therapies
are effective in lessening the severity and grading of OSMF. Additionally, student counseling to break bad habits
can lower the occurrence of OSMF.