QUANTITATIVE ANALYSIS OF DIFFERENT BRANDS OF DEXAMETHASONE TABLET MARKETED IN MAIDUGURI METROPOLITAN COUNCIL

Abstract

This experiment involves quantitative analysis of dexamethasone tablet marketed in Maiduguri Metropolitan Council using UV Spectrophotometry and HPLC method of analysis in which the samples were dissolved in methanol and their absorbance were determined and compared to that of the standard. Percentage content for each of the samples was determined so as to note if it was within the acceptable range of 90 110% in the British Pharmacopoeia (BP), for those that passed the test or, if it was below or above the range for samples that are substandard or highly concentrated. The amount of dexamethasone tablet in each sample was determined (actual content) and compared with that of the stated amount (0.5mg). It was observed that out of the eight samples (AARON’S, KRIS, NKOYO, DEXAREL, LOKELS, ANISUN, CHAZMAX and DEXA) three of the samples (NKOYO, LOKELS and DEXA) met the BP requirement for actual drug content range of 90 110% with percentage content of 98.1, 99.2 and 95.8% respectively, while the other five samples failed the test with values below and above the acceptable range.