DETERMINATION OF GANCICLOVIR IN BULK AND PHARMACEUTICAL DOSAGE FORMS BY UV SPECTROPHOTOMETRIC METHOD

Abstract

A Simple, rapid, accurate and economical UV Spectrophotometric method is developed for determination of Ganciclovir in bulk and tablets. In chloroform, the λmax of the drug was found to be 240 nm. Using double-beam Analytical Technologies Limited, model T60 UV-Visible spectrophotometer connected to computer loaded with UV Win 5.0 software, in this proposed method Ganciclovir follows linearity in the concentration range 1 – 40 μ g/ml with a correlation coefficient of 0.998. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.2319 with excellent precision and accuracy. The proposed method is specific while estimating the commercial formulations without interference of excipients and other additives. Hence, this method can be used for the routing determination of Ganciclovir in bulk samples and pharmaceutical formulations