SYNTHESIS OF 3H QUINAZOLIN 4 ONES CONTAINING PYRAZOLE AND PYRIMIDINONE MOIETIES AND ITS ANTIMICROBIAL SCREENING

Abstract

The emerging resistance to antimicrobial drugs demands the synthesis of new remedies for microbial infections, which are effective against organisms resistant to currently available drugs. A series of 2-benzyl-3-{4-[N'-(3-substituted-5-oxo-1-substituted-1,5-dihydropyrazole-4-ylidene)hydrazino]phenyl}-3H- quinazoline-4-one, derivatives were synthesized. The synthesized compounds were characterized by UV, IR, NMR, Mass spectral data. The synthesized compounds were screened for their antibacterial and antifungal activity against 8 pathogenic bacteria and 6 pathogenic fungus. Antimicrobial results indicated that, compounds showed significant activity against the tested fungi and bacteria’s. 3-[4-(3,5-dimethyl-1H-pyrazol-4-ylazo) phenyl]-2-benzyl-3H-quinazolin- 4-one exhibited good antibacterial and antifungal activity against the tested microorganisms.