THE COMBINATION OF PROPOLIS AND Curcuma zanthorrhiza AS ANTI-BREAST CANCER MATERIALS

Abstract

Breast cancer is the second leading cause of death after cervical cancer from the many deaths caused by cancer in women. Cancer treatment therapy is 
generally classified as expensive and has serious side effects. Propolis and Curcuma zanthorrhiza (Curcuma zanthorrhiza) have been widely tested by 
research institutions and have the potential to be anticancer. This study aimed to evaluate the synergy between anticancer activity of a combination of 
propolis and Curcuma zanthorrhiza extract against MCF-7 cancer cells using Response Surface Methodology (RSM). The test parameters observed 
were % inhibition of combination of propolis and Curcuma zanthorrhiza extract against MCF-7 cancer cells. Tests were carried out with 13 treatment 
combinations of extracts of propolis and Curcuma zanthorrhiza, negative control (cell growth media MCF-7) and positive control (doxorubicin) carried 
out in 3 replications in each treatment. The results showed that the LC50 and IC50 values obtained were in a higher concentration range compared to 
the LC50 and IC50 values of each extract.