Salbutamol Sulphate (SAL) and Cetirizine HCl (CET) is used for the treatment of asthma and allergy. A simple, economical, accurate and precise method for simultaneous estimation of Salbutamol Sulphate (SAL) and Cetirizine HCl (CET) in combined dosage form

Abstract

Salbutamol Sulphate (SAL) and Cetirizine HCl (CET) is used for the treatment of asthma and allergy. A simple, economical, accurate and precise method for simultaneous estimation of Salbutamol Sulphate (SAL) and Cetirizine HCl (CET) in combined dosage form has been developed. Simultaneous equation method based on measurement of absorbance at two wavelengths 276 nm and 230 nm, λmax of Salbutamol Sulphate (SAL) and Cetirizine HCl (CET) in 6.8 pH phosphate buffer. Both these drugs obeyed Beer Lambert’s law in the concentration range of 10-100 µg/ml for SAL and 2-20 μg/ml for CET. The high values of correlation coefficient (R²) indicated good linearity of calibration curve for both the drugs. The accuracy and precision of method was determined and the method validated stastically. Result of percentage recovery study confirms the accuracy of proposed method. The results of validation parameters indicates the accuracy of proposed methods for estimation of SAL and CET. Simultaneous equation method can be employed for routine analysis of SAL and CET in combined dosage form.