PROTECTIVE EFFECT OF PIMPINELLA TIRUPATIENSIS BAL. AND SUBR. AN ENDANGERED MEDICINAL PLANT OF TIRUMALA HILLS AGAINST STREPTOZOTOCIN GENERATED OXIDATIVE STRESS INDUCED DIABETIC RATS

Abstract

The present study was undertaken to investigate the effect of P. tirupatiensis, extract on antioxidant defense system of liver and pancreas against the streptozotocin-induced diabetic rats.

Ethyl acetate extract of P. tirupatiensis was administered orally for a period of 30 days (750 mg/kg BW) to diabetic rats. Fasting blood glucose level and malondialdehyde (MDA) were significantly augmented, whereas body weight, antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)) and non-enzymic antioxidants (reduced glutathione, (GSH), vitamin C and vitamin E) were reduced significantly in (STZ)-induced diabetic rats. However administration of P. tirupatiensis extract for a period of 30 days showed beneficial effects in all the biochemical parameters in (STZ)-induced diabetic rats. The present study indicates that extract of P. tirupatiensis modulates antioxidant activity and augments the defense against ROS generated damage in diabetic rats.